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This makes it desirable to pre-specify in a study protocol what meta-analysis method will be used, to avoid unjustified post-hoc analyses being performed to achieve statistical significance. We generally recommend that the one-stage method should be used. The one-stage method further facilitates the adjustment for other factors, which is particularly important in non-randomised settings.

Finally, stratification in one-stage models avoids the need for estimating correlations between random effects. One can simply estimate study-specific intercepts and slopes and place the random effect only on the factor of interest.